Today, the U.S. Food and Drug Administration is issuing a Safety Communication to inform patients and health care providers that devices claiming to clean, disinfect or sanitize continuous positive airway pressure (CPAP) devices or accessories (such as masks, tubing, headgear) using ozone gas or ultraviolet (UV) light are not legally marketed for this use by the FDA in the U.S., and as such, their safety and effectiveness for use with CPAP devices and accessories is unknown. CPAP devices are often prescribed for home use to patients with obstructive sleep apnea, a condition where an individual’s airway becomes blocked during sleep causing breathing to intermittently stop and start. CPAP devices use air pressure to keep airways open during sleep.

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To ensure the safe and effective cleaning of CPAP devices and accessories, the FDA is recommending that consumers and health care providers follow the cleaning instructions provided by the CPAP’s manufacturer, which normally include regular cleaning with soap and water.

“The FDA has identified several manufacturers that are marketing ozone gas or UV light-based products claiming to clean, disinfect or sanitize CPAP devices and accessories in the home,” said William H. Maisel, M.D., M.P.H, director of the Office of Product Evaluation and Quality in the FDA’s Center for Devices and Radiological Health. “Exposure to high levels of ozone gas may worsen a patients’ existing chronic respiratory diseases or increase the chance of a respiratory infection. UV light-based products could cause burns, eye damage or increase the risk of skin cancer due to over exposure. The FDA has contacted manufacturers of products making these claims and asked them to submit data demonstrating their safety and effectiveness.”

The FDA has received 11 reports from 2017-2019 from patients experiencing cough, difficult breathing, nasal irritation, headaches, asthma attacks and other breathing complaints when ozone gas-based products were used to clean, sanitize or disinfect CPAP devices and accessories. The FDA has not received any adverse event reports for UV light products claiming to clean, disinfect or sanitize CPAP devices and accessories.

Ozone is a gas that can be used to kill harmful bacteria. However, for ozone to be effective in killing harmful bacteria, it must be present at a concentration far greater than what is considered safe for humans. Although products claiming to clean, disinfect or sanitize CPAP devices that use ozone gas claim that they are designed to keep ozone gas inside the machine and its accessories, leaks can occur at tubing connections, filters or through containers used to house CPAP accessories. When leaks occur, ozone gas in the room where the devices are used may temporarily rise to unsafe levels especially if the room is small or not well ventilated.

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Additionally, if the CPAP machine or accessories are used without first allowing fresh air to circulate through the entire CPAP system to remove any remaining ozone gas, this could lead to someone inhaling ozone gas, which could cause breathing problems.

Direct exposure to UV light may cause injury depending on its wavelength, intensity and exposure time. Additionally, the UV light may not be able to penetrate all components of CPAP devices and accessories, like the plastic tubing, masks and connectors, which could lead to inadequately disinfected components that may be unsafe for people to reuse.

While these devices claiming to clean, sanitize or disinfect CPAP machines and accessories have not been FDA cleared or approved for marketing in the U.S., the FDA conducted its own preliminary lab testing on several of those illegally marketed products. The testing demonstrated ozone-using disinfection devices generated ambient levels of ozone above limits considered safe for human exposure. Ozone levels were also high in CPAP machines and tubing even after waiting the amount of time recommended by the ozone-based device manufacturer after a cleaning cycle. The FDA’s studies also showed the power of the UV light and time during which CPAP masks and accessories were exposed to this light varied considerably among UV cleaners. If CPAP components are exposed to insufficiently strong UV light or processed for an insufficient amount of time, the CPAP components could be inadequately disinfected leading to safety and performance issues.

The FDA has contacted manufacturers of the ozone gas and UV light products that claim to clean, sanitize or disinfect CPAP devices and accessories. Each manufacturer was informed that based on their product’s intended use and technological characteristics, FDA review and clearance or approval is needed and that data would need to be provided to demonstrate safety and effectiveness.

The FDA will continue to monitor reports of adverse events associated with the use of ozone gas or UV-based CPAP devices that claim to clean, sanitize or disinfect CPAP devices and accessories and update the public should new information become available.

The FDA encourages individuals to report adverse events related to the use these devices to the FDA.

The FDA, an agency within the U.S. Department of Health and Human Services, protects the public health by assuring the safety, effectiveness, and security of human and veterinary drugs, vaccines and other biological products for human use, and medical devices. The agency also is responsible for the safety and security of our nation’s food supply, cosmetics, dietary supplements, products that give off electronic radiation, and for regulating tobacco products.

Related Information

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Inquiries

Is it OK to use a disinfectant on my iPhone?
Using a 70 percent isopropyl alcohol wipe or Clorox Disinfecting Wipes, you may gently wipe the exterior surfaces of your iPhone. Don't use bleach. Avoid getting moisture in any openings, and don't submerge your iPhone in any cleaning agents.

iPhone 12, iPhone 12 mini, iPhone 12 Pro, iPhone 12 Pro Max, iPhone 11, iPhone 11 Pro, iPhone 11 Pro Max

iPhone 12, iPhone 12 mini, iPhone 12 Pro, iPhone 12 Pro Max, iPhone 11, iPhone 11 Pro, and iPhone 11 Pro Max feature glass with advanced textured matte finishes. On iPhone 12 mini, iPhone 12, and iPhone 11, the textured glass around the camera complements the polished glass. On iPhone 12 Pro, iPhone 12 Pro Max, iPhone 11 Pro, and iPhone 11 Pro Max, the textured back glass provides an elegant look that is also tough, slip resistant, and feels good in your hand. With normal use, the textured glass may show signs of material transfer from objects that come in contact with your iPhone, such as denim or items in your pocket. Material transfer may resemble a scratch, but can be removed in most cases.

Clean your iPhone immediately if it comes in contact with anything that might cause stains or other damage — for example, dirt or sand, ink, makeup, soap, detergent, acids or acidic foods, or lotions. Follow these guidelines for cleaning:

• Unplug all cables and turn off your iPhone.
• Use a soft, slightly damp, lint-free cloth—for example, a lens cloth.
• If material is still present, use a soft, lint-free cloth with warm soapy water.
• Avoid getting moisture in openings.
• Don’t use cleaning products or compressed air.

Your iPhone has a fingerprint-resistant oleophobic — oil repellent — coating. Cleaning products and abrasive materials will diminish the coating and might scratch your iPhone.

iPhone SE (2nd generation), iPhone XS, iPhone XS Max, iPhone XR, iPhone X, iPhone 8, iPhone 8 Plus, iPhone 7

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Clean your iPhone immediately if it comes in contact with anything that might cause stains or other damage — for example, dirt or sand, ink, makeup, soap, detergent, acids or acidic foods, or lotions. Follow these guidelines:

• Unplug all cables and turn off your iPhone.
• Use a soft, slightly damp, lint-free cloth — for example, a lens cloth.
• Avoid getting moisture in openings.
• Don’t use cleaning products or compressed air.

Your iPhone has a fingerprint-resistant oleophobic — oil repellent — coating. On iPhone 8 and later, the coating is on the front and back. This coating wears over time with normal use. Cleaning products and abrasive materials will further diminish the coating and might scratch your iPhone.

iPhone 6s, iPhone 6s Plus, iPhone 6, iPhone 6 Plus, iPhone SE (1st generation), iPhone 5s

Clean your iPhone immediately if it comes into contact with contaminants that might cause stains, such as ink, dyes, makeup, dirt, food, oils, and lotions. To clean your iPhone, unplug all cables and turn it off. Use a soft, slightly damp, lint-free cloth. Avoid getting moisture in openings. Don't use window cleaners, household cleaners, compressed air, aerosol sprays, solvents, ammonia, or abrasives to clean your iPhone. The front glass surfaces have an oleophobic coating. To remove fingerprints, wipe these surfaces with a soft, lint-free cloth. The ability of this coating to repel oil will diminish over time with normal use, and rubbing the screen with an abrasive material will further diminish its effect and might scratch the glass.

To clean the Home button (allowing Touch ID to work optimally), wipe it with a soft lint-free cloth.

iPhone 5c

Clean your iPhone immediately if it comes into contact with contaminants that might cause stains, such as ink, dyes, makeup, dirt, food, oils, and lotions. To clean your iPhone, unplug all cables and turn it off. Use a soft, slightly damp, lint-free cloth. Avoid getting moisture in openings. Don't use window cleaners, household cleaners, compressed air, aerosol sprays, solvents, ammonia, abrasives, or cleaners containing hydrogen peroxide to clean your iPhone. The front glass surfaces have an oleophobic coating. To remove fingerprints, wipe these surfaces with a soft, lint-free cloth. The ability of this coating to repel oil will diminish over time with normal use, and rubbing the screen with an abrasive material will further diminish its effect and might scratch the glass.

To clean the dirt that might accumulate around the SIM tray opening, use a soft lint-free cloth and place a very small amount of rubbing alcohol on it. Very gently wipe the dirt away from the port opening and avoid getting any of the moisture in the opening.

iPhone 5

Clean your iPhone immediately if it comes into contact with contaminants that might cause stains, such as ink, dyes, makeup, dirt, food, oils, and lotions. To clean your iPhone, unplug all cables and turn it off. Use a soft, slightly damp, lint-free cloth. Avoid getting moisture in openings. Don't use window cleaners, household cleaners, compressed air, aerosol sprays, solvents, ammonia, abrasives, or cleaners containing hydrogen peroxide to clean your iPhone. The front glass surfaces have an oleophobic coating. To remove fingerprints, wipe these surfaces with a soft, lint-free cloth. The ability of this coating to repel oil will diminish over time with normal use, and rubbing the screen with an abrasive material will further diminish its effect and might scratch the glass.

iPhone 4s and iPhone 4

Clean your iPhone immediately if it comes into contact with contaminants that might cause stains, such as ink, dyes, makeup, dirt, food, oils, and lotions. To clean your iPhone, unplug all cables and turn off your iPhone (press and hold the Sleep/Wake button, and then drag the onscreen slider). Use a soft, slightly damp, lint-free cloth. Avoid getting moisture in openings. Don't use window cleaners, household cleaners, compressed air, aerosol sprays, solvents, ammonia, abrasives, or cleaners containing hydrogen peroxide to clean your iPhone. The front and back glass surfaces have an oleophobic coating. To remove fingerprints, wipe these surfaces with a soft, lint-free cloth. The ability of this coating to repel oil will diminish over time with normal use, and rubbing the screen with an abrasive material will further diminish its effect and might scratch the glass.

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iPhone 3GS

Clean your iPhone immediately if it comes into contact with contaminants that might cause stains, such as ink, dyes, makeup, dirt, food, oils, and lotions. To clean your iPhone, unplug all cables and turn off your iPhone (press and hold the Sleep/Wake button, and then drag the onscreen slider). Use a soft, slightly damp, lint-free cloth. Avoid getting moisture in openings. Don't use window cleaners, household cleaners, compressed air, aerosol sprays, solvents, ammonia, abrasives, or cleaners containing hydrogen peroxide to clean your iPhone. The front glass surface has an oleophobic coating. To remove fingerprints, wipe these surfaces with a soft, lint-free cloth. The ability of this coating to repel oil will diminish over time with normal use, and rubbing the screen with an abrasive material will further diminish its effect and might scratch the glass.

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iPhone 3G and iPhone (original)

To clean your iPhone, unplug all cables and turn off your iPhone (press and hold the Sleep/Wake button, and then drag the onscreen slider). Then use a soft, slightly damp, lint-free cloth. Avoid getting moisture in openings. Don't use window cleaners, household cleaners, compressed air, aerosol sprays, solvents, ammonia, abrasives, or cleaners containing hydrogen peroxide to clean your iPhone.

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